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Oluwasola Michael Ojo
Olusola Isaac Aremu
Fatimah Omojoju Mustapha


Background: Many ocular and systemic conditions detected by eye care givers can be treated by the use of steroidal anti-inflammatory drugs (SAIDs), as well as Non-steroidal anti-inflammatory drugs (NSAIDs). Flurbiprofen is a non-steroidal anti-inflammatory drug usually prescribed in most eye clinic recently for the treatment of some eye diseases. The effect of Flurbiprofen on the tear production of 104 healthy participants was studied using their right eyes.


Methods: The participants with the mean age of 23.36 ± 4.28 years, consisted of 53 male participants and 51 female participants were selected after a thorough case history, external examination and ophthalmoscopy was done to rule out pathology. Schirmer’s test was done in all participants before instilling Flurbiprofen drops, the test was repeated at an interval of 30 minutes, for a period of one and half hours.


Results: The mean tear production reduced from baseline tear production 20.22mm to 15.63mm in the first 30 minutes, 13.95mm in 60 minutes and 14.90mm in 90 minutes. This amounts to a reduction of 4.59 (22.70%), 6.27 (31.01%), 5.32 (26.31%) at 30, 60 and 90 minutes respectively. These reductions were found to be statistically significant (P > 0.05) showing that Flurbiprofen significantly inhibits tear production. 


Conclusion: Flurbiprofen should therefore be used with caution in individuals that have or are predisposed to dry eye syndrome.


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Ojo, O. M., Aremu, O. I., & Mustapha, F. O. (2022). ACUTE EFFECT OF FLURBIPROFEN (IVYFLUR) ON TEAR PRODUCTION. Nigerian Journal of Pharmaceutical and Applied Science Research, 10(3), 10–16. Retrieved from


Carreno E, Portero A, Galarreta DJ and Herreras JM. Update on dosage of Flurbiprofen. Clinical Ophthalmology 2012, 6: 637-644.

Medzhitov R. Origin and Physiological roles of inflammation. Nature, 2008, 454:428-435.

Cho H. and Wolf KJ. Management of Ocular Inflammation and Pain Following Cataract Surgery: Focus on Flurbiprofen Ophthalmic Solution. Clinical Ophthalmology, 2009, 3: 199-210.

Flach AJ. Topical non-steroidal anti-inflammatory drugs in Ophthalmology. International Clinical Ophthalmology, 2002, 42: 1-11.

El-harazi SM, Ruiz RS and Feldman RM. A randomized double-masked trial comparing ketorolac tromethanline 0.5%, diclofenac sodium 0.1%, and prednisole acetate 1% in reducing post-phacoemulsification flare and cells. Ophthalmic Surgery, Lasers and Imaging Retina (1998), 29(7): 539-544.

Roberts CW. Comparison of diclofenac sodium and flurbiprofen for inhibition of surgically induced miosis. Journal of Cataract & Refractive Surgery, 1996, 22(1): 780-787.

Shaughnessy M J, Harsanyi A, Li J, Bright T and Murphy CD. Targeted Fluorination of a non-steroidal anti-inflammatory drug to prolong metabolic half-life. ChemMedChem(2014), 9(4):733-736.

Farandos NM, Yetisen AK, Monetri MJ, Lowe CR and Yun SH. Contact Lens Sensors in Ocular Diagnostics. Advanced Health Care Materials, 2014, 4(6): 792-810.

Darrt DA and Willcox MD. Complexity of the Tear film: Importance in Homeostasis and Dysfunction during Disease. Experimental Eye Research, 2013, 117:1-3.

Ihesiulor C G, Uka MC, Offorha BC, Nwokike CC, Udo UA, Anonaba C A and Ebere AO. A Prospective study of the effect of bromfenac on tear production. Matrix Sci Med (2019), 3:1-5.

Corandy CD, Joos ZP and Patel BCK. "Review: The Lacrimal Gland and its Role in Dry Eye". Journal of Ophthamology 2016, 16: 11.

Hessen M. Dry Eye: Master the Science Beneath the Surface. Review of Optometry [online]: available from: (Accessed 22 November 2019).

Hiroshi F, Miki F, Masarou O and Dogu M. Efficacy of Non-steroidal anti-inflammatory drugs for the treatment of Dry eye Disease. Asia Pacific Journal of Ophthalmology, 2015, 4: 9-13.

Haeringen NJ, Sorge AA, Delft JL. and Carballosa VM. Flurbiprofen and Enantiomers in Ophthalmic Solution tested as Inhibitors of Prostanoid Synthesis in Human Blood. Ocular Pharmacology, 2000, 345-352.

Crandall DC. The influences of systemic drugs in tear constituents. Journal of Ophthalmology, 1999, 86: 115-125.

Nicholas K, Zadnick MK. "The repeatability of clinical measurements of Dry eye" Cornea, 2006, 23(3): 272-285.

Hirase LB, Button FN, and Christoe CC. Effect of Age on Tear Production rate. American Journal of Optometry, 1994, 8: 400-441.

Khistie R and Penland S N. Gaba ergineurosteroid modulation of ethanol actions. World Journal of Psychiatric Medicine, 2002, 3: 87-95.