Antiulcerogenic activity of leaf extract of Saccharum officinarum (Poaceae) in rodents

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Published: Sep 20, 2023
DOI: https://doi.org/10.60787/nijophasr-v12-i2-509
Keywords:
Antiulcerogenic, gastrointestinal disorders, Saccharum officinarum, ulcer

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Utibe A. Edem
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
John A. Udobang
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Nigeria
Augustine L. Bassey
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Nigeria
Uchechukwu L. Iyanyi
Department of Clinical Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University, Elele Campus, Rivers State, Nigeria
Jude E. Okokon
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Nigeria

Abstract

Background:Saccharum officinarum (Family-Poaceae) is used in Ibibio ethnomedicine for the treatment of various diseases such as malaria and gastrointestinal disorders. The study aimed to evaluate the antiulcerogenic activity of the leaf extract against experimentally-induced ulcer in rats.


 


 Methods:The leaf extract  of S. officinarum (170-510 mg/kg) was investigated for antiulcer activity in rodents using indomethacin, ethanol and histamine-induced ulcer  models in overnight fasted Wistar rats weighing 125-150 g. The rats were randomized into different groups and treated with extract and ulcerogens. The stomachs of the animals were removed, examined for ulcerations and scored accordingly.


   


Results: The leaf extract (170-510 mg/kg) was found to exert significant (p<0.05-0.001) and dose-dependent activity against indomethacin, ethanol and histamine-induced ulcers.


 


Conclusion: These results suggest that the leaf extract of Saccharum officinarum possesses antiulcerogenic potential which is due to the activities of the phytochemical constituents which can be explored for the treatment of ulcers.

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How to Cite
A. Edem, U., A. Udobang, J., L. Bassey, A., L. Iyanyi , U., & E. Okokon, J. (2023). Antiulcerogenic activity of leaf extract of Saccharum officinarum (Poaceae) in rodents. Nigerian Journal of Pharmaceutical and Applied Science Research, 12(2), 22–27. https://doi.org/10.60787/nijophasr-v12-i2-509
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Vol. 12 No. 2 (2023): June: Nigerian Journal of Pharmaceutical and Applied Science Research (NIJOPHASR)
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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