Neutraceutical and antibacterial properties of methanol extract of Plukenetia conophora [Müll.-Arg. family Euphorbiaceae] leaves and physical properties of its cream formulations
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Abstract
The neutraceutical and antibacterial properties of methanol extract of the leaves of Plukenetia conophora were studied as well as physical properties of creams formulated with the extracts. Phytochemical analyses of the contents of the extract were determined using standard methods. The antimicrobial assay of the extracts was investigated and the quality and stability of the creams formulated with the extracts were also studied. Proximate analysis for the extract revealed 6.86±0.07% moisture, 11.78±0.42% protein, 8.57±0.14% total ash, 20.12±0.74% crude fibre, 1.56±0.42% total fat and 51.85±0.08% total carbohydrate. The phytochemical groups identified include alkaloids, cardenolides, flavonoids, sugars, and tannins. Polyphenolic content analysis of the extract revealed:- total flavonoids (78.27mg/g), total proanthocyanidins (73.50mg/g) and total phenolic acids (110.71mg/g). Mineral content analysis showed that the extract had some vital minerals. The antibacterial assay of the extracts displayed activity against Proteus mirabilis and Bacillus subtilis. The formulated creams passed the physical and stability studies that were carried out.The phytochemicals present in the extracts indicate the wide range of physiological and medicinal activities of the extract and thus support the folk use of Plukenetia conophora as a nutraceutical and antimicrobial. Furthermore, the extract could be formulated as creams with desirable physical properties and stability.
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